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A showdown between Super Bowl and NFL MVP-winning quarterbacks, a key AFC contest and a reunion of bitter rivals highlight the Week 4 schedule.

Kansas City’s Patrick Mahomes will play Tampa Bay’s Tom Brady on Sunday Night Football, Buffalo and Baltimore will hold a battle of 2-1 AFC teams with Super Bowl aspirations and the Commanders and Cowboys will resume their longtime rivalry.

Here’s everything you need to know about the NFL odds for Week 4 — the point spreads, moneylines, total over/unders and betting results(with all NFL odds via FOX Bet).

All times ET

SUNDAY’S GAMES

Vikings @ Saints in London (9:30 a.m., NFL Network)

Point spread: Vikings -3 (Vikings favored to win by more than 3 points, otherwise Saints cover)
Moneyline: Vikings -167 favorites to win (bet $10 to win $15.99 total); Saints +130 underdogs to win (bet $10 to win $23 total)
Total scoring over/under: 43.5 points scored by both teams combined

Minnesota Vikings

MIN

New Orleans Saints

NO

RELATED: How to Bet Vikings-Saints

Browns @ Falcons (1 p.m., CBS)

Point spread: Browns -1.5 (Browns favored to win by more than 1.5 points, otherwise Falcons cover)
Moneyline: Browns -125 favorites to win (bet $10 to win $18 total); Falcons +100 underdogs to win (bet $10 to win $20 total)
Total scoring over/under: 47.5 points scored by both teams combined

Cleveland Browns

CLE

Atlanta Falcons

ATL

RELATED: How to Bet Browns-Falcons

Commanders @ Cowboys (1 p.m., FOX)

Point spread: Cowboys -3 (Cowboys favored to win by more than 3 points, otherwise Commanders cover)
Moneyline: Cowboys -162 favorites to win (bet $10 to win $16.17 total); Commanders +125 underdogs to win (bet $10 to win $22.50 total)
Total scoring over/under: 41.5 points scored by both teams combined

Washington Commanders

WAS

Dallas Cowboys

DAL

RELATED: How to Bet Commanders-Cowboys

Seahawks @ Lions (1 p.m., FOX)

Point spread: Lions -3.5 (Lions favored to win by more than 3.5 points, otherwise Seahawks cover)
Moneyline: Lions -189 favorites to win (bet $10 to win $15.29 total); Seahawks +145 underdogs to win (bet $10 to win $24.50 total)
Total scoring over/under: 47.5 points scored by both teams combined

Seattle Seahawks

SEA

Detroit Lions

DET

RELATED: How to Bet Seahawks-Lions

Titans @ Colts (1 p.m., FOX)

Point spread: Colts -3.5 (Colts favored to win by more than 3.5 points, otherwise Titans cover)
Moneyline: Colts -189 favorites to win (bet $10 to win $15.29 total); Titans +145 underdogs to win (bet $10 to win $24.50 total)
Total scoring over/under: 42.5 points scored by both teams combined

Tennessee Titans

TEN

Indianapolis Colts

IND

RELATED: How to Bet Titans-Colts

Bears @ Giants (1 p.m., FOX)

Point spread: Giants -3 (Giants favored to win by more than 3 points, otherwise Bears cover)
Moneyline: Giants -154 favorites to win (bet $10 to win $16.49 total); Bears +120 underdogs to win (bet $10 to win $22 total)
Total scoring over/under: 39.5 points scored by both teams combined

Chicago Bears

CHI

New York Giants

NYG

RELATED: How to Bet Bears-Giants

Jaguars @ Eagles (1 p.m., CBS)

Point spread: Eagles -6.5 (Eagles favored to win by more than 6.5 points, otherwise Jaguars cover)
Moneyline: Eagles -303 favorites to win (bet $10 to win $13.30 total); Jaguars +220 underdogs to win (bet $10 to win $32 total)
Total scoring over/under: 45.5 points scored by both teams combined

Jacksonville Jaguars

JAX

Philadelphia Eagles

PHI

RELATED: How to Bet Jaguars-Eagles

Is Tom Brady or Patrick Mahomes under more pressure in Week 4? | SPEAK

Jets @ Steelers (1 p.m., CBS)

Point spread: Steelers -3.5 (Steelers favored to win by more than 3.5 points, otherwise Jets cover)
Moneyline: Steelers -182 favorites to win (bet $10 to win $15.49 total); Jets +140 underdogs to win (bet $10 to win $24 total)
Total scoring over/under: 41.5 points scored by both teams combined

New York Jets

NYJ

Pittsburgh Steelers

PIT

RELATED: How to Bet Jets-Steelers

Bills @ Ravens (1 p.m., CBS)

Point spread: Bills -3 (Bills favored to win by more than 3 points, otherwise Ravens cover)
Moneyline: Bills -167 favorites to win (bet $10 to win $15.99 total); Ravens +130 underdogs to win (bet $10 to win $23 total)
Total scoring over/under: 51.5 points scored by both teams combined

Buffalo Bills

BUF

Baltimore Ravens

BAL

RELATED: How to Bet Bills-Ravens

Chargers @ Texans  (1 p.m., CBS)

Point spread: Chargers -5.5 (Chargers favored to win by more than 5.5 points, otherwise Texans cover)
Moneyline: Chargers -278 favorites to win (bet $10 to win $13.60 total); Texans +205 underdogs to win (bet $10 to win $30.50 total)
Total scoring over/under: 44.5 points scored by both teams combined

Los Angeles Chargers

LAC

Houston Texans

HOU

RELATED: How to Bet Chargers-Texans

Cardinals @ Panthers (4:05 p.m., FOX)

Point spread: Cardinals -1.5 (Cardinals favored to win by more than 1.5 points, otherwise Panthers cover)
Moneyline: Panthers -118 favorites to win (bet $10 to win $18.47 total); Cardinals -105 underdogs to win (bet $10 to win $19.52 total)
Total scoring over/under: 43.5 points scored by both teams combined

Arizona Cardinals

ARI

Carolina Panthers

CAR

RELATED: How to Bet Cardinals-Panthers

Patriots @ Packers (4:25 p.m., CBS)

Point spread: Packers -9.5 (Packers favored to win by more than 9.5 points, otherwise Patriots cover)
Moneyline: Packers -455 favorites to win (bet $10 to win $12.20 total); Patriots +280 underdogs to win (bet $10 to win $38 total)
Total scoring over/under: 39.5 points scored by both teams combined

New England Patriots

NE

Green Bay Packers

GB

RELATED: How to Bet Patriots-Packers

Broncos @ Raiders (4:25 p.m., CBS)

Point spread: Raiders -2.5 (Raiders favored to win by more than 2.5 points, otherwise Broncos cover)
Moneyline: Raiders -149 favorites to win (bet $10 to win $16.71 total); Broncos +115 underdogs to win (bet $10 to win $21.50 total)
Total scoring over/under: 45.5 points scored by both teams combined

Denver Broncos

DEN

Las Vegas Raiders

LV

RELATED: How to Bet Broncos-Raiders

Chiefs @ Buccaneers (8:20 p.m., NBC)

Point spread: Buccaneers -1 (Buccaneers favored to win by more than 1 point, otherwise Chiefs cover)
Moneyline: Buccaneers -118 favorites to win (bet $10 to win $18.47 total); Chiefs -105 underdogs to win (bet $10 to win $19.52 total)
Total scoring over/under: 45.5 points scored by both teams combined

Kansas City Chiefs

KC

Tampa Bay Buccaneers

TB

RELATED: How to Bet Chiefs-Buccaneers

MONDAY’S GAME

Rams @ 49ers (8:15 p.m., ESPN)

Point spread: 49ers -1.5 (49ers favored to win by more than 1.5 points, otherwise Rams cover)
Moneyline: 49ers -125 favorites to win (bet $10 to win $18 total); Rams +100 underdogs to win (bet $10 to win $20 total)
Total scoring over/under: 42.5 points scored by both teams combined

Los Angeles Rams

LAR

San Francisco 49ers

SF

RELATED: How to Bet Rams-49ers

Our experts have you covered on everything you need for this weekend from a betting perspective:

Warren Sharp’s Betting Edges

Geoff Schwartz’s Best NFL Bets

Pat Everson’s Sharp Bets

Jason McIntyre’s Favorite NFL Bets

Sammy’s Best College football and NFL Picks

Geoff’s Best College Football Wagers

Patrick Everson on how Unders and prime-time Unders are dominating

COMPLETED GAME

Bengals 27, Dolphins 15

Point spread: Bengals (-3.5) cover by winning by more than 3.5 points (12)
Moneyline: Bengals win as -213 favorites (bet $10 to win $14.69 total); Dolphins were +160 underdogs (bet $10 to win $26 total)
Total scoring over/under: Under 46.5 points scored by both teams combined (42)

Miami Dolphins

MIA

Cincinnati Bengals

CIN

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